Scientist, Protein Purification A career in Boston - main video (youtube.com) At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. The US Structural Biology Center of Excellence (CoE) at GSK, a new joint Vaccine and Pharma Center, will be established in Cambridge, MA in 2025. The mission of the CoE is to apply the full range of structural biology, protein biochemistry, and computational tools to design vaccines as well as antibodies, biologics, and small molecule drugs. We're looking for a passionate and highly motivated scientist to join the CoE. As a crucial member of our team, you will deploy your scientific knowledge in recombinant protein production from mammalian, bacterial and/or insect expression systems. The position will require active collaboration with diverse team to work together and address key challenges. You will be expected to maintain our laboratory environment and introduce new methods/protocols related to your specific area of expertise. Your time-management and organization skills will be highly valued. This position offers you the opportunity to actively contribute to multiple pipeline projects simultaneously and directly impact the progression of our preclinical vaccine candidates. You will need to anticipate problems, proactively seek solutions, and balance competing priorities to be successful. This role interacts directly with both upstream and downstream counterparts to enable smooth communication and hand-off of materials. You will also have the opportunity to interact with scientists based in other centers and countries, ensuring that you can access the most up-to-date knowledge and capabilities to efficiently fulfill your missions. This position will initially be located at the GSK's Rockville site in Maryland from 2024 to 2025, and will permanently move to Cambridge, Massachusetts afterwards. Key Responsibilities: Propose, implement, maintain, and deliver existing and/or new capabilities for the purification of proteins. Collaborate with the protein expression, molecular design, biophysics, and structural biology teams to ensure the correct prioritization of samples and the timely delivery of the protein production pipeline. Deliver high quality materials with appropriate control experiments and documentation. Maintain the equipment and manage the consumables in the purification laboratory. Interpret the results of experiments and update protocols accordingly. Keep current with the latest developments and techniques in the field. Ensuring safety procedures and regulations are followed in the laboratory. Present research findings and updates in internal reports, project meetings, and external scientific meetings when appropriate. Basic Qualifications: BSc or MSc in protein biochemistry, cell biology, biology, molecular biology or related field. BSc and 4+ years of experience. MSc and 2+ years of experience. Minimum of two years of hand-on experience, preferably in an industrial research environment, national lab and/or other core facility structure Two or more years of protein purification techniques including affinity purification, size exclusion, anion exchange, and/or multi-modal techniques One or more years of experience with buffer exchange, TFF, and related process techniques. Two or more years of experience purifying protein from mammalian cell culture including HEK293 and/or CHO cell lines. One or more years of expeirnece in the operation and maintenance of AKTA systems Preferred Qualifications: PhD in protein biochemistry, cell biology, biology, molecular biology or related field Experience with the purification of proteins from different protein expression systems including bacterial, insect and/or yeast. Ability to further characterize purified material for endotoxin contamination and/or bioburden. Ability to further characterization purified material using biophysical techniques including HPLC, nanoDSF, BLI, SPR and/or mass photometry. Excellent oral and written communication skills with a fluency in English. Able to efficiently manage uncertainty, changes in priority and timeline restrictions. Excellent problem-solving skills and the ability to troubleshoot technical issues. Demonstrated ability to work independently and as part of a diverse team. Demonstrated ability to manage competing priorities and stakeholders. Strong communication skills #Vx-Cam #Li-GSK The annual base salary for new hires in this position ranges from $85,850 to $116,150 taking into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. 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