Scientist, Chemical Engineering

Agios Pharmaceuticals Inc • Full-time • Cambridge, Massachusetts, United States • $95k - $145k / year • 2w ago

Scientist, Chemical Engineering

Who we are:

Agios is a biopharmaceutical company that is fueled by connections. We thrive in a supportive, fun, and flexible environment full of people empowered to bring their whole selves to work. We care deeply about our work, each other, and the patients who count on us. Our teams cultivate strong bonds with patient communities, healthcare professionals, partners and colleagues, which helps us discover, develop and deliver therapies for rare disease - and make a bigger difference in their lives. In the U.S., Agios markets a first-in-class pyruvate kinase (PK) activator for the treatment of hemolytic anemia in adults with PK deficiency. Building on the company's leadership in the field of cellular metabolism, Agios is advancing a robust clinical pipeline of investigational medicines with active and planned programs in alpha- and beta-thalassemia, sickle cell disease, pediatric PK deficiency and MDS-associated anemia.

The impact you will make:

Agios Pharmaceuticals is searching for a dynamic Chemical Engineer to join our growing Chemistry Process Research and Development team. We want someone who cares about this important work, and who's driven to connect to our mission of helping these patient communities. The Scientist will maintain engineering service and capabilities to support the development and manufacture of drug substance including reaction optimization, crystallization process development, particle engineering for all CMC projects from DC enabling activities to commercial process validation. The incumbent will proactively interact with CMC project leaders, chemists, formulators to identify opportunities to apply engineering principles during process development to enhance process understanding, assess scale up risks and accelerate process development.

What you will do:

Collaborate with a team to oversee and support drug substance manufacturing activities, including process design, optimization, scale-up, and technology transfer
Provide technical support within the Drug Substance group, including troubleshooting, investigations, process improvements, and the implementation of new manufacturing technologies
Assist in optimizing chemistry processes by utilizing Design of Experiments (DoE), production data, in-process controls (IPCs), and manufacturing information to enhance efficiency
Responsible for material characterization and analysis to support process understanding and development
Manage CROs/CDMOs for material solid-state development
Support crystallization development and establish PSD control strategies
Author and/or review pertinent SOP's and manufacturing process instructions
Manage external teams to address technical issues encountered in the above areas

Good to have:

Material science background in small molecule solid-state development, focusing on polymorph, co-crystal and salt screening, characterization and selection
Computational modeling and simulation experience to understand material physicochemical properties, reaction kinetics, and process scale down/up
Extensive experience in the application of various analytical instruments
Good knowledge for process safety evaluation

What you bring:

PhD in chemical engineering or related field with 2-6 years of experience working within a pharma/innovator company, MS with extensive experience will also be considered
Work seamlessly within a process chemistry department to support all programs
Strong attention to detail and the ability to multi-task in fast paced environment
Strong interpersonal skills and the ability to effectively work individually, within a cross-functional team
Strong oral and written communication skills
Strong team player that is solution oriented with positive, energetic and proactive attitude
Record of scientific contribution through publications and presentations

Work Location:

Location Specific - Onsite: This role requires the majority of work to be completed onsite at our Cambridge Headquarters. While it is expected that this role will be onsite a minimum of 4 days a week, Agios values flexibility, and flexible schedules around onsite work are available. Regular conversations with manager are encouraged to ensure alignment on in-person presence/expectations. Employees in this role are expected to live within a commutable distance to the office.

What we will give you:

Deliberate Development. Your professional growth as one of our top priorities.
Flexibility. We're all about individual needs. We embrace different perspectives, work styles, health and wellness approaches, care of families and productivity. When you're at your best, we're at our best.
Premium benefits package. We invest in the health, wellbeing and security of our people with a premium benefits package that is well-rounded and flexible to help meet the varied personal and professional needs of every member of our team.
Competitive performance-based compensation. This includes both short- and long-term incentives that are connected to our business strategy.
Psychological safety. We support an environment of fearlessness. We want you to share your ideas, speak candidly and take data-informed risks to help push the boundaries.
Commitment to diversity. We strive to foster a welcoming workplace where everyone can thrive. We're continuously looking to improve the inclusivity of our workforce.
Commitment to community. We're an active participant in the communities that surround us - the communities where we live, and the community of people and their loved ones in need of better treatment options for conditions that are often overlooked.

Interested in learning more about what makes our culture unique? Visit the Inside Agios section of our website.

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