Marengo Therapeutics is pioneering first-in-class therapeutics that activate the right immune response to promote lifelong protection against cancer. Marengo has uncovered a novel approach to T cell activation by targeting the Vß TCR chain to unleash rapid, potent, and long-lasting anti-tumor immune responses safely and effectively. We're leveraging our versatile, proprietary bispecific fusion protein platform to selectively deliver the right activation to the right T cell subsets, customizable to patient needs with its tunable properties, with an initial focus on advanced solid tumors and broad applicability beyond.

Marengo is driven by core values that guide our company's mission and approach from the inside out: we demonstrate an unparalleled commitment to patients and their loved ones, we are confident in our science and our team, we operate with courage, and we creatively apply deep expertise to new ways of thinking with curiosity and imagination. With an exciting journey ahead and a tremendous opportunity for growth, now is the time to join the Marengo team and impact cancer patient care - are you ready to join the new frontier?

To learn more, visit marengotx.com.

Role: Senior Scientist, Structural Bilogist & Modeler

Overview: This position is a dry lab/wet lab hybrid scientist role within the "Antibody Technologies & CMC (ATC)" function, reporting to the head of our Protein Sciences group. The ideal candidate is highly motivated, versatile, and experienced in biopharmaceutical process research and analytical sciences to support both discovery and development projects. This individual will perform computational protein design and structural biology analysis across many projects across Marengo's pipeline. Candidates should have demonstrated hands-on experience in structure computation and modeling using workstations and/or high-performance cloud servers. Successful applicants will also be required to interface with Antibody Discovery and Biology teams and provide input on protein engineering projects. He/she should also demonstrate a good understanding of cutting-edge machine learning and structural biology tools for protein engineering and design.

Requirements

Who are we looking for?

• You are an experienced structural biologist who likes to think out of the box and is passionate about the company's mission of discovering and developing new medications

• You are a resourceful self-starter and team player with a strong results orientation

What are we looking for?

• A driven professional who knows how to work and contribute to an ever-changing working environment

• A collegial individual who enjoys working in close collaboration with leaders in the research, development, manufacturing, quality, clinical, and administrative areas of the company

• A willingness to learn new things, adapt to new ways, and go with the flow

• A person who thrives in a small company atmosphere

• Ability to determine task priority and maintain established deadlines

What are we offering?

• Membership within a growing, CARING, and collegial organization

• Being part of a passionate, involved, and cutting-edge Finance Team

• Exposure to pioneering science and the discovery of drugs to help treat patients with cancer

Responsibilities:

• Establish computational structural modeling and protein engineering workflows with the latest developments in structural biology, machine learning, and antibody engineering.

• Integrate computational tools with experimental structural biology analysis to support structure-function relationships for optimization and design of protein therapeutics.

• Collaborate with the Antibody Discovery team to deliver protein engineering solutions.

• Carry out hands-on wet lab experiments, including protein production and biophysical characterization, to support structural biology and pipeline program needs.

• Manage collaborations with external CROs.

• Act as a Subject Matter Expert in computational structure modeling and guide the research project teams.

• Analyze and present data, both in written reports and oral presentations.

• Exhibit versatility to take on new responsibilities within the Protein Sciences group.

• Act as a champion and represent the Antibody technologies team in project team meetings and participate in data presentations and cross-functional collaborations with the opportunity to serve as ATC lead.

Education and Experience:

• PhD in Biochemistry, Structural Biology or a closely related field and 5+ years' experience in extensive structure computation and protein modeling is required

• A proven track record of computational structural modeling using up-to-date programs, such as Alphafold and Rosetta, and analysis of structure-function relationships is required

• Solid understanding of protein structures and recent developments in machine learning for structural biology and antibody engineering

• Expertise in characterization of proteins for cryoEM and other biophysical methods

• Experience working in a matrix environment

• Attention to detail and a creative approach mentality to problem-solving

• Highly analytical mind, attention to detail, and organizational skills are critical

• Self-motivated with a strong sense of responsibility, integrity, and a collaborative spirit

• Ability to work independently to design and troubleshoot experiments

• Versatile and quick learner to take on new responsibilities and implement new technologies

Competencies:

Adaptability: Responds resourcefully, flexibly, and positively when faced with new challenges, transitions, and demands. Willingly and effectively deals with the stress and complexities of various situations. Moves forward productively and optimistically under conditions of change and uncertainty.

Collaboration: Embodies and promotes collaboration and works effectively with others across the organization to achieve goals. Demonstrates proficient cross-company communication, cultural sensitivity, and partnership in interactions with others. Involves others in decisions and plans and credits them for their contributions and accomplishments.

Execution: Drives execution of strategic and operating plans while maintaining operational effectiveness. Conveys a strong sense of urgency around continuous improvement, achieving high-quality results, and accelerating business performance. Addresses problems directly and drives

changes necessary to achieve business objectives.

Relationship Building: Establishes and maintains strong relationships internally and externally. Respects and relates well to management, colleagues, peers, and direct reports. Champions a culture of respect, diversity, and inclusion that values and respects individuals. Earns the respect of others through principled leadership, sound business ethics, and authenticity.

Location: Cambridge, MA ( We are located in Lower Cambridge, called Cambridgeport)

When You Join Marengo, You Will Have:

In addition to the compensation, we offer the following benefits:

• Free parking, Cambridge location reachable by public transportation (Red Line)

• Customized and competitive health coverage, including medical offered through BCBS (HMO/PPO), dental, and vision

• Flexible Spending Accounts for medical and dependent care expenses

• Eligible from the first day for 401K, no matching

• A robust package of Marengo-paid insurance coverage, including life insurance, short-term and long-term disability, and parental leave

• 20 days of vacation and one personal day, and 64 hours of sick time per year, in addition to 16 company holidays

TO ALL AGENCIES: Please, no phone calls or emails to any employee of Marengo about our openings. All resumes submitted by search firms/employment agencies to any employee at Marengo via email, the internet or in any form and/or method will be deemed the sole property of Marengo unless such search firms/employment agencies were engaged by Marengo for this position and a valid agreement with Marengo is in place. In the event a candidate who was submitted outside of the Marengo agency engagement process is hired, no fee or payment of any kind will be paid.

Marengo Therapeutics, Inc. is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service or any other class protected by state or federal law.

Marengo Therapeutics, Inc. jobs

Senior Scientist, Structural Biologist and Modeler